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The oldest type of surgery - Trepanation It has been practiced by people since the Stone Age. Nowadays it is an integral part of almost all neurosurgical operations - it is how surgeons gain access to intracranial formations. Trepanation is performed by making holes in the skull and crossing the bone between these holes How did things work during the Stone Age? In a similar way, but, ahem, by different methods. It is also worth mentioning that trepanation was performed not only for medical purposes, but also for ritual purposes.