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Assistant Professor Кирилл Половников из Нейроцентра открыл сессию по складыванию и динамике генома на ежегодной встрече "Физика живых систем" в Триесте, Италия.
В своем докладе Кирилл представил результаты своего исследования по экструзии петель на хромосомах, недавно опубликованного в журнале Physical Review X, входящем в Nature Index.
Работа показывает, что ДНК структурно организована в случайные петли и предлагает модель полимерной физики, объясняющую, как петли влияют на статистику контактов в хромосомах. Полная презентация доступна на YouTube (на английском языке).
Встреча проходила в Международном центре теоретической физики Абдуса Салама, европейском исследовательском центре по физическим и математическим наукам.
I used to silence for communication
Where words had no any place:
I was trying a lot to came close to her
But, She was making some space,
I asked :- Why ?
She replied :- Getting someone is not really love
Because,"Full stop is the end of sentence".
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Ali Shamkhani, the senior political advisor to Iran's Supreme Leader, tweeted in Persian, Chinese, English, Russian and Hebrew - in response to Netanyahu's speech last night at the JNS conference.
He writes:
Netanyahu: "We will destroy Iran's nuclear reactors; only complete destruction of Iran's nuclear capability is acceptable." The consequences for Israel could be unimaginable. Are these threats an independent decision by #Israel, or coordinated with #Trump in #talks with #Iran?
To comment, follow this link
22 апреля т.г. состоялось мероприятие, на котором председатель Яккасарайского межрайонного суда по гражданским делам Г. Эргашев и заместитель председателя суда Г. Хамраева выступили с докладом для сотрудников Агентства по иностранным инвестициям, Агентства по продвижению экспорта и Агентства по международному сотрудничеству и развитию при Министерстве инвестиций и внешней торговли о системе противодействия коррупции в Узбекистане . В ходе выступления председатель суда рассказал о пошаговых мерах, принимаемых в Узбекистане по предотвращению коррупции в рамках реализации Стратегии развития Нового Узбекистана на 2022 — 2026 годы, а также уменьшению человеческого фактора посредством цифровизации принятия решений на местах.
В конце мероприятия участники получили подробные ответы на интересующие их вопросы.
#uzipa#anti_corruption#talks
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How a demilitarized zone would be governed has also been a sticking point. Ukraine has pressed for an international peacekeeping force to be deployed to the region, which is home to 190,000 civilians including 12,000 children, according to the area’s Ukrainian governor.
The negotiators discussed forming a civilian administration to rule the area after the war, two of the three people familiar with the talks said.
This could include both Russian and Ukrainian representatives, one of the people said, but the person noted that the sides are far from an agreement.
Another issue that has re-emerged recently is the sequencing of the various steps, including accepting a demilitarized zone, formalizing security guarantees, creating a framework for postwar reconstruction funding and holding elections in Ukraine.
Last week, Zelensky said Ukraine wanted an agreement on security guarantees before committing to an election or any agreement on withdrawing forces from the Donbas.
“I would very much like us to sign security guarantees first and then sign other documents,” he said.
“In my view, that would be a good signal. This is not even a matter of fairness, but a matter of trust. More trust in partners — if guarantees come first, and then everything else.”
Zelensky said Ukrainians must “know — not just believe, but know — that in the future Russian aggression will be impossible or that if it does happen, we will not be alone.”
#zelensky#peace#talks#putin
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Zelensky Was Upbeat Before the Last Peace Talks — Wants To Meet Putin
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The latest round of talks to end the war in Ukraine concluded on Wednesday without any sign of meaningful progress.
But behind the scenes, negotiators have been trying to find a compromise on one of the biggest obstacles to a peace deal: control of territory in eastern Ukraine.
Russia has demanded that Ukraine hand over the land it controls in the Donetsk region as a condition for ending the war.
This is a strip of territory about 50 miles long and 40 miles wide that includes dozens of towns and villages, and sits between the frontline and the administrative border of the region.
Ukraine has refused to withdraw unilaterally, saying that ceding land would embolden Russia to attack again, in Ukraine or elsewhere. Kyiv has asked for security guarantees to deter Moscow from violating any cease-fire.
In negotiations over recent weeks, officials have discussed the idea of forming a demilitarized zone controlled by neither army, according to three people familiar with the talks who would only speak anonymously to discuss sensitive negotiations.
This revives a proposal that was included in prior peace plans, including a 28-point one floated by the Trump administration in November.
Over the past week, President Volodymyr Zelensky of Ukraine has repeatedly downplayed the prospects of surrendering land for peace. “Allowing the aggressor to take something is a big mistake,” he wrote on social media on Monday.
Last fall, President Vladimir V. Putin of Russia was noncommittal when asked about forming a demilitarized zone in the Donbas region.
The 28-point plan would have put Russia in charge of the area but prohibited it from deploying military forces there. Mr. Putin said the details needed to be discussed.
The Russian president’s foreign policy adviser, Yuri Ushakov, was later more positive, saying Russia could accept the formation of such an area if Russian police or national guard soldiers were allowed to patrol it.
A demilitarized zone could become part of a viable settlement, said William Taylor, a fellow at the Atlantic Council, a think-tank, and a former U.S. ambassador to Kyiv.
But Ukraine’s interests would have to be protected, he said, and that would require the Trump administration to apply additional pressure on Russia.
“It is important that it be a real solution, not a forced solution, not an unbalanced solution,” Taylor said. “Any forced solution will not be stable. It will not last.”
To make it easier for both sides to accept the idea, negotiators have also discussed forming a free-trade zone in any possible demilitarized area, though investment possibilities seem limited in a territory that would be wedged between two armies, even with a cease-fire in place.
Most industry in the area is in ruins, with only one coal mine still operational, and the risk that the conflict could be rekindled would loom for years.
Zelensky has also cast doubt on such an arrangement.
Another issue is the withdrawal of troops from the frontline. In December, Zelensky suggested Ukraine would not withdraw troops from the frontline unless Russia withdrew by an equal distance.
At talks held in Abu Dhabi this month, the Ukrainians discussed options for a partial Russian withdrawal from the frontline that would not necessarily be symmetrical, two of the three people familiar with the talks said. This would signal a softening of Ukraine’s position.
#zelensky#peace#talks#putin
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Iran Botched Up Nuclear Talks With the US
Plans for U.S.-Iran nuclear talks on Friday are back on, after several Middle Eastern leaders urgently lobbied the Trump administration on Wednesday afternoon not to follow through on threats to walk away.
The talks will be held in Oman, as Iran insisted, despite the U.S. initially rejecting changes to the original plan to meet in Istanbul.
The standoff had sparked fears across the Middle East that Trump would pivot to military action.
At least nine countries from the region reached out to the White House at the highest levels strongly urging the U.S. not to cancel the meeting.
"They asked us to keep the meeting and listen to what the Iranians have to say. We have told the Arabs that we will do the meeting if they insist. But we are very skeptical," one U.S. official said.
A second U.S. official said the Trump administration agreed to hold the meeting "to be respectful" to U.S. allies in the region and "in order to continue pursuing the diplomatic track."
The U.S. and Iran had agreed to meet on Friday in Istanbul, with other Middle Eastern countries participating as observers.
But the Iranians said on Tuesday that they wanted to move the talks to Oman and hold them in a bilateral format, to ensure that they focused only on nuclear issues and not other matters like missiles that are priorities for the U.S. and countries in the region.
U.S. officials were at first open to the request to change the location, then rejected it, before reversing course once again, the meeting was off.
Iranian Foreign Minister Araghchi confirmed on X that talks were "scheduled to be held in Muscat on about 10 am Friday," adding:
"I'm grateful to our Omani brothers for making all necessary arrangements."
#nuclear#talks#US#oman
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Iran has also targeted Gulf countries that host US military bases. Airports in Kuwait, Abu Dhabi and Dubai were damaged by missiles and remained shut on Sunday, causing one of global aviation’s most severe disruptions in years.
“They want to talk, and I have agreed to talk, so I will be talking to them,” he told the Atlantic magazine, without revealing when those talks may start.
“They should have done it sooner. They should have given what was very practical and easy to do sooner. They waited too long.”
In remarks to the Daily Mail, Trump suggested the conflict with Iran could go on for the next four weeks. He also said there could be more American casualties and vowed to avenge American deaths.
He was speaking as the global effects of the war began to be felt. The price of oil rose after two reported attacks on tankers in or near the strait of Hormuz.
The ship attacks were a reminder of the conflict’s potential to trigger an environmental catastrophe.
In launching the war, Trump said it would provide an opportunity for the Iranian people to rise up and overthrow the 47-year-old Islamic regime.
Nationwide protests earlier this year were brutally suppressed by security forces, and some estimates say tens of thousands of civilians were killed.
The Iranian authorities said that 22 border guards at Mehran, on the Iranian-Iraqi border, had been killed, a sign that the US and Israel were seeking to weaken the regime’s control of Iran’s borders in support of anti-government separatists.
Across the country, Iranians said they felt a mixture of terror and optimism as the bombings continued. Some expressed relief that the long-expected strikes had arrived and opponents of the regime spoke of hope that they may lead to political change.
Both were tempered by fear that the attacks would bring more civilian deaths to a country already reeling from recent bloodshed.
Larijani accused the US and Israel of trying to plunder and fragment Iran and warned “secessionist groups” of a harsh response if they attempted to intervene, state television said.
The regime in Tehran insisted that Khamenei’s killing would not weaken its resolve. Iran’s parliament speaker, Mohammad Bagher Ghalibaf, said Netanyahu and Trump had “crossed a red line” and “will pay for it”, according to state media.
Iran’s president, Masoud Pezeshkian, said a leadership council composed of himself, the judiciary head and a member of the powerful Guardian Council had temporarily assumed the duties of supreme leader until a replacement was chosen.
Trump shrugged off the suggestion that the economic fallout from the war could damage the Republican party’s prospects in November’s congressional elections.
#trump#iran#talks#tehran#pezeshkian
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Will Trump Bully Tehran Into Submission ?
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Trump said on Sunday he was prepared to talk to what was left of the Iranian leadership after the killing of the country’s supreme leader by US-Israeli airstrikes aimed at overthrowing the regime.
Trump was speaking as a second day of intense bombing of Iranian cities and Tehran’s missile counterattacks sent tremors across the region and through the global economy.
On Monday the conflict spread to Lebanon as Israel began striking Hezbollah targets, after the group launched missiles and drones towards Israel’s north in retaliation for the killing of Ayatollah Ali Khamenei.
Iran’s top security official, Ali Larijani, who was also an adviser to the country’s former supreme leader, said on Monday that Tehran would not negotiate with the US, and denied reports that officials had sought to initiate talks with the Trump administration.
Amir-Saeid Iravani, the Iranian ambassador to the UN, told an emergency security council meeting on Saturday that hundreds of civilians had been killed or injured in the US-Israeli strikes. He said they had deliberately targeted civilian neighbourhoods in multiple cities.
The death toll is expected to climb after a second day of bombing. Iranian state media said that 165 people had been confirmed dead in a bomb attack on a girls’ primary school in the southern city of Minab on Saturday.
Among the dead was Khamenei, who had ruled as Iran’s supreme leader since 1989 and was the primary target of an initial Israeli strike on Saturday morning.
According to several US reports, the CIA had been tracking Khamenei for months. The New York Times reported that the CIA tipped off Israel when the leader convened a meeting of top defence aides at his compound in Tehran, triggering a decision to strike.
Israel’s Channel 12 reported that the Israeli army employed a ruse to put the Iranian leadership off its guard. On the morning of the operation, army officers were asked not to park their cars in their usual spaces to avoid detection by Iran’s spies. Misinformation was also leaked suggesting that the chief of staff Lt Gen Eyal Zamir had stayed at home.
The channel cited officials as saying the Israeli air force killed 30 high-ranking Iranian officials within the first 30 seconds of the attack.
Trump told Fox News that 48 Iranian leaders had been killed in the first two days of bombing, and claimed in a social media post that nine Iranian warships had been sunk and the naval headquarters destroyed.
“The attack was so successful it knocked out most of the candidates (…) It’s not going to be anybody that we were thinking of because they are all dead,” Trump said, according to Karl’s reports.
Nine Israelis have so far died in Iranian missile counterstrikes, and US forces confirmed their first casualties of the war: three dead and five injured by shrapnel. The official announcement did not give details on where and how the casualties occurred.
#trump#iran#talks#tehran#pezeshkian
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The US secretary of state, Marco Rubio, has also said Iran’s refusal to discuss its ballistic missile programme is a problem, prompting Iran’s foreign ministry spokesperson, Esmaeil Baghaei, to complain about inconsistencies in the US negotiating demands.
The talks are being held against the backdrop of Trump’s unprecedented buildup of US assets in the region, including two aircraft carrier strike groups, attack aircraft, plane-refuelling equipment and submarines equipped with Tomahawk missiles.
At heart of the talks is whether the US will try to debar Tehran from almost all uranium enrichment. The right to enrich uranium domestically has long been seen as a symbol of Iranian national sovereignty, and was conceded by the US in the 2015 nuclear deal.
Some of the dispute about enrichment can be deferred since Trump claimed that Iran’s three main nuclear facilities at Fordow, Natanz and Isfahan had been obliterated by US bombs last June, making it technically impossible to enrich uranium in high quantities for the foreseeable future.
Tehran refused to allow the UN’s nuclear watchdog, the International Atomic Energy Agency (IAEA) to inspect the scale of the damage to the sites since the US attack.
Rubio said on Wednesday: “They’re not enriching right now, but they’re trying to get to the point where they ultimately can.”
One Iranian official in Geneva insisted: “The principles of zero enrichment for ever, dismantling of nuclear facilities and transferring uranium stocks to the US is completely rejected.”
Trump now has the military assets in place to strike Iran either as part of an extended assault designed to enforce regime change, or to carry out a more targeted strike designed to force Tehran into a more flexible negotiating position.
Trump’s coercive negotiating deadlines have always been flexible, but his military commanders will not want to keep such a large and expensive concentration of forces on a leash for much longer.
Rubio said on Wednesday that the ballistic missile programme would have to be addressed at some point, an admission that the subject may not be on the immediate agenda, but could not be disbarred from later talks.
He said: “Iran refuses to discuss the range of its missiles with us or anyone else, and this is a big problem for us. Iran has missiles that increase their range every year, and this could be a threat to the United States because the range of the missiles may reach American soil.” Its short-range missiles could also hit US bases in the region, he noted.
#us#iran#war#talks#nuclear#missiles
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