Post #369

New Psychedelics compounds search. Why? Deal with First gen psychedelic issues: - they were not created specifically to threat a particular disorder even if can do it with a certain efficacy - they have cardiotoxicity related to 5ht2b mechanism - long action duration length for therapy New hopes and ideas: - decouple halucenogetic from therapeutic effect - potentially reaching even newer states of mind - targetly engineered experience without so complex set and setting What? - Kanna alcaloids for premature ejaculation 😅 - BPL-003 for Treatment Resistant Depression (TRD). - IHCH-7113 Non halucenogetic psychedelic for depression - Ele-101 for depression and Alcohol Use Disorder (AUD). How? 1. AI assisted search - Predictive AI. Train on structure to properties (need big dataset of both) - Generative AI. Evolutionary machines 2. Natural compounds search and enchantment - Research existing less popular natural compounds rom indigenous communities - Enchance properties (Increase a half life, change blood barrier penetration, etc.. 3. Future approaches - computational chemistry (compounds VS receptors ) - test on brain organoids Skill level: #intermediate https://youtu.be/BQoIozpBU5Y